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The mean auc increased by about 1 -fold for hydroxybupropion and about 2 -fold for threo erythrohydrobupropion.

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in healthy subjects, prasugrel increased bupropion cmax and auc values by 14 and 18 , respectively, and decreased cmax and auc values of hydroxybupropion, an active metabolite of bupropion, by 32 and 24 , respectively.



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